大阪歯科大学 教員情報

発表言語	英語
発表タイトル	Palatal mucosal wound healing after administration of an antibacterial drug in type 2 diabetes model rats
学会名	第61回歯科基礎医学会学術大会
発表形式	ポスター掲示
発表者・共同発表者	Uemura M, Orihara H, Sumi Y, Moriue K, Kawashima W, Toda I
発表年月	2019/10/12
開催地	東京都
学会抄録	「J. Oral Biosci.」　Suppl.(325)
概要	We investigated the effect of antibiotic administration on spontaneous healing in Goto-Kakizaki (GK) rats with type 2 diabetes and an experimentally formed defect in the palatal mucosa, comparing a control group of 18 male 8-week-old Wistar rats and a diabetes mellitus (DM) group of 18 male 8-week-old GK rats. In both groups, a cylindrical defect 1.5 mm in diameter was formed in the maxillary right first molar region of the palatal mucosa using a biopsy punch to remove all the soft tissue, including the periosteum. Immediately after this surgery, an antibiotic was administered intraperitoneally. Three animals per group were sacrificed for histological specimen at healing periods of 1, 3, 5, 7, 14 and 28 days after the surgery. It took longer for the wound to be covered with epithelium in the DM group than in the control group, and the appearance of granulation tissue and collagen fibers in the lamina propria was delayed. No sequestrum formation occurred in either group. The results of our comparative histological observations showed that spontaneous healing was delayed in GK rats compared with the controls. Our results suggest that if an antibiotic is administered, sequestrum formation may not occur. Conflict of Interest: The authors declare no conflict of interest. Conflict of Interest: The authors declare no conflict of interest.