| 論文種別 |
原著 |
| 記述言語 |
英文 |
| 表題 |
Induction of mesenchymal stem cells-like cells rerived from human gingival iPS cells into osteoblast-like cells. |
| 掲載誌名 |
Journal of Oral Tissue Engineering
|
| 巻（号）：頁 |
15(2):85 |
| 著者・共著者名 |
Nakayama Y, Hashimoto Y, Honda Y, Matsumoto N |
| 発行年月 |
2017/12 |
| 概要 |
Mesenchymal stem cells (MSCs) have a limited capacity to proliferate in vitro, making it very difficult to acquire sufficient cell numbers for implantation. The objective of this study was to induce MSC-like cells (MSLCs) from human gingival induced pluripotent stem cells (iPSCs) into osteoblast-like cells. We fabricated MSLCs from human gingival iPSCs under the feeder free condition. MSLCs expressing MSC-specific markers treated with osteoblast differentiation factor expressed osteoblast-specific mRNA and protein. Given the higher proliferative capacity of MSLCs, the cells may be a possible source for preparing osteoblast-like cells, applicable for bone regeneration therapy. |
| DOI |
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