| 論文種別 |
原著 |
| 記述言語 |
英文 |
| 表題 |
Involvement of the NMDA Receptor in Learning and Memory in Rats with Neuropathic Pain |
| 掲載誌名 |
Journal of Osaka Dental University
(ISSN:04752058) |
| 巻（号）：頁 |
43(1):83-91 |
| 著者・共著者名 |
Andoh T, Sakuma Y, Kotani J |
| 発行年月 |
2009/04 |
| 概要 |
It is known that the N-methyl-D-aspartate (NMDA) receptor is important for learning/memory capability and neuropathic pain. Although it has been reported that NMDA receptor antagonists cause learning/memory disorders, they are effective for neuropathic pain. We investigated the relation between the NMDA receptor and learning/memory capability using neuropathic pain chronic constriction injury (CCI) model rats on the 8-arm radial maze and the step-through type passive avoidance apparatus. The CCI model rats performed better on the tests than either the normal animals or those that had received NMDA receptor antagonists. These findings suggest that the neuropathic pain of the CCI rats raised their learning/memory ability through the NMDA receptor. |
| DOI |
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