大阪歯科大学 教員情報
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	ホンダ　ヨシトモ   本田　義知   歯学部 歯学科   主任教授
■ 最終学歴・学位 1. 東北大学大学院 歯学研究科 博士課程修了 博士（歯学）
■ 著書 1. 茶ポリフェノールの生理機能と応用展開  2019/09 2. 無機/有機材料の表面処理・改質による生体適合性付与  2019/05 3. 歯科再生・修復医療と材料  2015/08
■ 学術研究論文 1. Green tea catechin at a daily intake level suppresses root resorption while maintaining intrusive tooth movement in rat model  2026/01 2. Force-dependent presence of senescent cells expressing vascular endothelial growth factor during orthodontic tooth movement  2026/01 3. Physicochemical and Antioxidant Alterations of Modified and Free Epigallocatechin Gallate Under Thermal Treatment in Air and Vacuum  2025/12 4. Screening of Salivary Biomarkers of Bisphosphonate-Related Osteonecrosis of the Jaw in a Diabetic Rat Model  2025/11 5. Sustained fisetin release prevents orthodontic Ti-6Al-4V screw failure by suppressing peri-implantitis and alveolar bone resorption  2025/02 6. Cellular senescence of RANKL+ osteoblasts and Th17 cells in severe periodontitis with occlusal trauma  2025/02 7. Histomorphometric analysis of external apical root resorption using L-loops and different intrusive forces  2024/12 8. Cmpk2 gene and protein expression in saliva or salivary glands of dyslipidemic mice  2024/12 9. Temporal changes toward cellular senescence in rat dental pulp stem cells induced by long-term in vitro culture  2024/12 10. Mesenchymal stem cell extract promotes skin wound healing  2024/12 全件表示 11. Detection of senescent cells in the mucosal healing process on type 2 diabetic rats after tooth extraction for biomaterial development  2024/06 12. Influence of LPS concentration and number of dehydrothermal treatments on properties of lipopolysaccharides sustained-release gelatin  2024/06 13. Exploration of reference genes for the development of a diagnostic kit on vascular aging in human saliva.  2024/04 14. Senescence-associated secretory phenotypes in rat-derived dedifferentiated fat cells with replicative senescence.  2023/05 15. RANKL+ senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics.  2023/05 16. Application of Senescent Cells in Regenerative Medicine.  2023/05 17. Aggravation of cellular senescence in human periodontal fibroblasts cultured with tobacco smoke components by stretching stimulation.  2023/04 18. 歯科疾患におけるストレス誘導性早期老化細胞の関与の解明とバイオマテリ アルを応用した新戦略  2023/04 19. Localization of senescent cells under cavity preparations in rats and restoration of reparative dentin formation by senolytics.  2023/03 20. Identification of senescent cells in peri-implantitis and prevention of mini-implant loss using senolytics  2023/01 21. Development of a tooth movement model of root resorption during intrusive orthodontic treatment  2023/01 22. The effect of different surgical instruments for bone regeneration under the surgery of bone defect on rat calvaria.  2022/04 23. Sustained stimulation by low-dose lipopolysaccharide prolongs trabecular structure deterioration and immaturity of collagen at regenerated bone even after bone volume recovery.  2022/02 24. Utility of thermal cross-linking in stabilizing hydrogels with beta-tricalcium phosphate and/or epigallocatechin gallate for use in bone regeneration therapy.  2022/01 25. Tailoring silicon nitride surface chemistry for facilitating odontogenic differentiation of rat dental pulp cells.  2021/12 26. ストレス誘導性老化細胞を標的にした診断・治療法開発の取り組み.  2021/11 27. Enhancement of bone-forming ability on beta-tricalcium phosphate by modulating cellular senescence mechanisms using senolytics.  2021/11 28. Comparison of osteogenic potentials of dental pulp and bone marrow mesenchymal stem cells using the new cell transplantation platform, cellsaic, in a rat congenital cleft-jaw model.  2021/09 29. Development of an assay to determine expression levels of ERBB2 and SIRT1 mRNA in saliva.  2021/04 30. Smoking cessation rescues tooth movement delays caused by tobacco smoke components.  2020/12 31. Bone regeneration using rat-derived dedifferentiated fat cells combined with activated platelet-rich plasma.  2020/11 32. Gas permeability of mold during freezing process alters the pore distribution of gelatin sponge and its bone-forming ability.  2020/10 33. Inhibitory effect of galloyl moiety in epigallocatechin gallate for gelation of gelatin.  2020/10 34. ストレス誘導性老化と骨再生.  2020/07 35. Augmentation of bone regeneration by depletion of stress-induced senescent cells using catechin and senolytics.  2020/06 36. Detection of biomarkers on aging and vascular senescence in saliva  2020/04 37. Sustained release of catechin from gelatin and its effect on bone formation in critical sized defects in rat calvaria.  2020/04 38. 細胞外環境制御と植物由来物物質 ～緑茶由来カテキンを応用した新規骨再生材料開発～.  2020/03 39. Releasing behavior of lipopolysaccharide from gelatin modulates inflammation, cellular senescence, and bone formation in critical-sized bone defects in rat calvaria.  2019/12 40. Integration of epigallocatechin gallate in gelatin sponges attenuates matrix metalloproteinase-dependent degradation and increases bone formation.  2019/11 41. 植物由来物質（カテキン）の高機能化による新規骨再生材料開発.  2019/09 42. Controlled synthesis of glycopolymers with pendant complex-type sialylglycopeptides and their binding affinity with a lectin and an influenza virus.  2019/09 43. Comparison of the characteristics of mesenchymal stem-like cells derived by integration-free induced pluripotent stem cells in different single-cell culture media under feeder-free conditions.  2019/06 44. A study about stress undergoing dental treatment in patients with gagging reflex.  2019/04 45. Repetitive learning of English dental terms for dental university students  2019/03 46. The first synthesis of periodic and alternating glycopolymers by raft polymerization: a novel synthetic pathway for glycosaminoglycan mimics.  2019/01 47. 大阪歯科大学における環境問題への取り組みとグリーンケミストリーを用いた再生医療材料の開発.  2018/12 48. Effect of nanoparticles on biofilm-growth disruption: silver and platinum nanoparticles with an identical capping agent.  2018/12 49. Osteogenesis of multipotent progenitor cells using the epigallocatechin gallate-modified gelatin sponge scaffold in the rat congenital cleft-jaw model.  2018/12 50. Single local injection of epigallocatechin gallate-modified gelatin attenuates bone resorption.  2018/12 51. Epigallocatechin gallate-modified gelatins with different compositions alter the quality of regenerated bones.  2018/10 52. カテキンとゼラチンで創る再生医療材料  2018/08 53. Simulation training for medical emergencies in the dental setting using an inexpensive software application.  2018/08 54. Surface modification of porous alpha-tricalcium phosphate granules with heparin enhanced their early osteogenic capability in a rat calvarial defect model.  2018/07 55. Effects of C60 fullerene on cell differentiation and cell viability of mouse iPS cells.  2018/06 56. Epigallocatechin gallate-modified gelatin sponges treated by vacuum heating as a novel scaffold for bone tissue engineering.  2018/04 57. カテキン結合ゼラチンスポンジ：水中での合成と骨再生医療への応用.  2018/03 58. 緑茶由来成分の再検討・機能化から始まった骨再生材料開発.  2018/01 59. Interferon-gamma enhances the efficacy of autogenous bone grafts by inhibiting postoperative bone resorption in rat calvarial defects.  2016/07 60. Mono- and dinuclear gadolinium(III) complexes of tris(4-carboxy-3-benzyl-3-azabutyl) amine: Synthesis and relaxation properties  2016/02 61. Evaluation of bone regeneration by porous alpha-tricalcium phosphate/atelocollagen sponge composite in critical-sized rat calvarial defects.  2016/01 62. Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria.  2015/12 63. Application of green tea catechin for inducing the osteogenic differentiation of human dedifferentiated fat cells in vitro.  2015/11 64. The effect of interferon-γ and zoledronate treatment on alpha-tricalcium phosphate/collagen sponge-mediated bone-tissue engineering.  2015/10 65. Local controlled release of polyphenol conjugated with gelatin facilitates bone formation.  2015/06 66. Supplementation of strontium to a chondrogenic medium promotes chondrogenic differentiation of human dedifferentiated fat cells.  2015/05 67. The utility of human dedifferentiated fat cells in bone tissue engineering in vitro.  2015/01 68. A comprehensive mixture of tobacco smoke components　retards orthodontic tooth movement via the inhibition of osteoclastogenesis in a rat model.  2014/10 69. Effect of addition of hyaluronic acids on the osteoconductivity and biodegradability of synthetic octacalcium phosphate.  2014/01 70. Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control  2013/12 71. Characterization and bioactivity of nano-submicro octacalcium phosphate/gelatin composite.  2013/10 72. Development of sutable scaffold based on tilapia fish collagen for the long-term differentation culture of embryonic stem cells.  2013/09 73. An attempt to in vitro embryotoxicity test using mouse ES cells and human hepatocytes.  2013/09 74. Labile Zn ions on octacalcium phosphate-derived Zn-containing hydroxyapatite surfaces.  2013/05 75. Structural, morphological and surface characteristics of two types of octacalcium phosphate-derived fluoride-containing apatitic calcium phosphate  2012/12 76. Cortical bone tissue response of injectable octacalcium phosphate-hyaluronic acid complexes  2012/11 77. Stimulatory capacity of an octacalcium phosphate/gelatin composite on bone regeneration in rabbit tibia defect model  2012/09 78. Comparative study on in vitro cytotoxicity of synthetic octacalcium phosphate and calcium phosphate ceramics used clinically  2012/06 79. Granule size-dependent bone regenerative capacity of octacalcium phosphate in collagen matrix  2012/05 80. The effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects  2012/03 10件表示
■ 学会発表 1. バイオマテリアルを用いた疾患モデリング -ストレス誘導性老化細胞と歯科疾患の関係解明を目指して-（口頭発表，特別・招待講演等）  2025/12/13 2. 歯科矯正時に出現するRANKL陽性老化細胞を標的とした歯根吸収予防法の開発（口頭発表）  2024/06/01 3. 細胞形態や核形態に着目した多能性前駆細胞への複製老化の影響（ポスター，一般）  2024/03/22 4. 生体材料を用いた老化細胞制御（口頭発表，特別・招待講演等）  2023/09/05 5. シン・老化研究と歯科疾患（口頭発表，特別・招待講演等）  2023/05/20 6. 細胞老化と再生医療（口頭発表）  2022/10/07
■ 受賞学術賞 1. 2008 東北大学総長賞 2. 2009/01 The 3rd International Symposium Interface Oral Health Science Excellent Young Investigator Award 3. 2009/10 第54回　日本歯科理工学会学術講演会　研究奨励賞 4. 2011/02 第32回　東北骨代謝研究会　優秀演題賞 5. 2013/10 第62回　日本歯科理工学会学術講演会　発表優秀賞 6. 2015/08 第24回　硬組織再生生物学会学術大会　優秀発表賞 7. 2024/06 第24回日本抗加齢医学会総会 優秀演題賞
■ 資格・免許 1. 歯科医師 2. Dental Materials Senior Adviser 3. 再生医療認定医